visit homepage. Physicians frequently prescribe Zoloft for anxiety. Zoloft is the brand for a generic form of sertraline hydrochloride. It’s a prescription drug and used to treat depression as well as a wide range of many other severe mental health problems apart from anxiety. Whenever a patient uses Zoloft for anxiety, it functions in the brain as a selective serotonin reuptake inhibitor. As a SSRI, Zoloft prevents the reabsorption of serotonin in the brain. Although this mechanism is really not entirely understood, it is presumed that serotonin controls a person’s emotional state.